Active Clinical Trials and Research Studies

Research Studies Need Participants

When we look back at the advances that have been made over the last 20 years in Alzheimer’s research and review recent research advances, we feel very hopeful that 20 years from now we will be able to prevent the current devastating effects of the disease. Each step forward requires people willing to participate in research.

This charts below is a summary of all actively enrolling studies. If you are interested in participating in a research study, please call 404-727-6050 or gadrc.recruitment@emory.edu.

Browse by Focus Area

Early Detection & Diagnosis

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Study Description

This study looks at the differences between people who get Alzheimer's disease early (before age 65), those who get it later, and older adults without memory problems. The goal is to better understand what causes Alzheimer's and how it affects the brain.

Eligibility Criteria

• Normal: CDR = 0
• Normal: MMSE 26-30
• EOAD: CDR ≤ 1.0
• Ages: 40-64

DIAN-TU-002

Study Description

The purpose of this research study is to test the study drug, referred to as remternetug, to determine its effectiveness for the study treatment of asymptomatic (at risk) Alzheimer's disease in individuals with AD-causing mutations. This study will also investigate the effects of remternetug on biomarkers (measures of the disease, including brain scans, blood, and spinal fluid tests), examine safety data to identify any potential benefits or risks, and examine how well participants can tolerate remternetug.

Eligibility Criteria

• Age ≤ 65
• 11-25 years of estimated onset for their affected relative
• Asymptomatic (normal CDR=0)

Brain Health & Aging

Emory Healthy Aging Study (EHAS)

Study Description

The Emory Healthy Aging Study is a longitudinal study focused on helping us better understand how we age and age-related disease through the creation of a large database of health history information provided by participants.

Eligibility Criteria

• Read and speak English fluently
• Age: 18+

Emory Healthy Brain Study (EHBS)

Study Description

The Emory Healthy Brain Study is a longitudinal sub-study of the Emory Healthy Aging Study focused on identifying the biomarkers of Alzheimer's disease and other forms of dementia.

Eligibility Criteria

• Currently enrolled in the Emory Healthy Aging Study (EHAS)
• Ages: 50-75

HONOR / Memory / UDS

Study Description

Memory at Emory is a longitudinal study designed to learn more about neurologic disorders. Criteria for participation includes individuals 70 years of age or older.

Eligibility Criteria

• Cognitively Normal; MCI; PD
• Minorities, specifically AA (not necessarily for PD cohort)
• Willing to do lumbar puncture, brain scan (MRI)
• Age: Over 70 years old

SuperAger

Eligibility Criteria

• TICS score must be > 33
• Age: 80+

Precision Aging Network (PAN)

Study Description

The Precision Aging Network seeks help to answer critical questions: What impacts healthy brain function as we age? How can optimal brain function be maintained across our entire lives? For you as an individual, how can we predict, prevent, or slow unwanted changes in cognition?

Eligibility Criteria

• Age 18 or older can be involved virtually
• Individuals aged 50-79 without a diagnosis of cognitive impairment can be involved in-person

Treatment & Intervention

ALLFTD (Longitudinal Frontotemporal Lobar Degeneration)

Study Description

The ALLFTD study looks at people with a brain disease called frontotemporal dementia (FTD), including those who have it and family members who might get it. The goal is to learn how the disease changes over time and help with future treatments. The study has two parts: one does a full check-up every year, and the other collects only basic health info and body samples like blood or saliva.

Eligibility Criteria

• FTLD diagnosis
• Age: 30+

Benfo Study

Study Description

The Benfo study tests if boosting thiamine in the brain can slow cognitive decline in people with MCI and mild AD.

Eligibility Criteria

• Age 50-89 years old
• Dx: early AD, MCI or mild dementia and amyloid positive
• MMSE 20-30, <26

Caregiver & Lifestyle Support

Charlie and Harriet Shaffer Cognitive Empowerment Program (CEP)

Study Description

The Charlie and Harriet Shaffer Cognitive Empowerment Program aims to provide people with Mild Cognitive Impairment (MCI) and their Care Partners and families with an opportunity to participate in comprehensive lifestyle programs that promote joy, purpose, health, and wellness. Members of the program will receive personalized assessments designed to empower them as they seek to implement healthy brain interventions.

Eligibility Criteria

• Clinic patient with MCI

Biorepository & Donation

Goizueta Institute Biorepository

Study Description

Study enrollment includes individuals over the age of 18. All patients seen by an Emory Brain Health provider or an Emory Primary Care provider.

Eligibility Criteria

• Age: 18+
• Emory Brain Health or Primary Care patient
• Participants with cognitive decline need a care partner to accompany them during their visit

Brain Donation Program

Study Description

The purpose of this research study is to follow individuals who have participated in ACTC and/or ATRI research studies, over the phone every 6 months, until the time of death. All participants who join this study are registered members of the ACTC Brain Donation Program.

Eligibility Criteria

• Previous participation in ACTC clinical study

Different Types of Research Studies

Research on Alzheimer’s is rapidly advancing on several fronts.

Researchers are:

• Testing potential new medications they hope will be even more effective than currently available treatments
• Using medications approved for other uses (for example, cholesterol lowering medications) as potential treatments for Alzheimer’s 
• Looking for ways to identify mild cognitive impairment and Alzheimer’s disease early as well as monitor the progress of the disease
• Learning more about the transition from aging without memory problems to mild cognitive impairment and Alzheimer’s
• Studying how to help individuals and families cope with the disease